J Clin Exp Med Nowadays high concentrations of OPCs are sold to save storage space. In summary, this study verifies that hemoperfusion and hemodialysis on the basis of routine treatment can improve the success rate of clinical rescue, and improve the prognosis of patients, which is worthy of clinical popularization and application for treating organophosphorus pesticides poisoning patients with renal insufficiency. Overall mortality rate was Mechanical ventilation was immediately given if ventilation-related indications appeared.

OP compounds are used worldwide in agriculture as well as in household gardens. The age of these patients ranged within 19 to 66 years, with an average age of Epigenetic and autophagy studies are useful to address the issues related to regulation of gene and protein expression by which nerve agents could impact on human health. In this article, we report the retrospective analysis of patients with severe OP insecticide poisoning in a tertiary care hospital in Northern India. Stomach decompression was carried out in all patients with nasogastric tubes; Li et al. Most patients with intermediate syndrome develop respiratory failure, which requires mechanical ventilation. The results of this study revealed the following:

The treatment group comprised 34 patients, including 18 male and 16 female patients.

Lipid emulsion treatments are commonly used in resuscitating OP poisoning patients but few studies regarding their use thessi been reported.

The work cannot be changed in any way or used commercially without permission from the journal. Department of Anaesthesiology, J. Overall mortality rate was The duration of mechanical ventilation increased with the increase in lag time.


Intern Med China ; Experience with intensive care management of organophosphate insecticide poisoning. Multivariate binary logistic regression analysis was done with death as the dependent variable and age, lag time to PAM therapy, severity of poisoning and duration of ventilation as the covariates.

In the present study, the incidence was highest in patients aged less than 40 years. Patients requiring ventilatory support were initially put on assist pressure control mode and subsequently weaned off by synchronised intermittent mandatory ventilation SIMVpressure support PS ventilation.

organophosphate poisoning

Observation and treatment of acute complications during the hemodialysis. Positive end expiratory pressure PEEP was added as per the lung characteristics. Cholinesterase reactivators cannot pass through blood—brain barrier, so pralidoxime iodide combined with atropine is restricted in the treatment. Though each predictor age, lag time, severity of poisoning and duration of ventilation is associated with mortality, death due to OP poisoning results from overlapping contribution of these factors.

Key to survival lies in early diagnosis followed by rapid decontamination and definitive therapy which purely lies under the expert domain of emergency medicine. Eddleston M, Phillips MR. Initial management of all patients with pralidoxime PAM and atropine were done as per the recommended dosage schedule.

thesis on opc poisoning

Please review our privacy policy. Diagnosis of OP poisoning depends mainly on history, characteristic clinical presentation and is supplemented by decreased levels of serum and erythrocyte cholinesterase levels.

It should be administered as soon as possible to prevent ageing and promote adequate reactivation of red cell acetylcholinesterase. Prophylactic potential of memantine against soman poisoning in rats. Open in a separate window.


thesis on opc poisoning

According to Kumar et al. Poisoning due to organophosphate insecticides.

Most recent papers with the keyword organophosphate poisoning | Read by QxMD

Innurse specialists in poison information joined the IPIC. In the present retrospective analysis, the overall mortality was This signifies that death due to OP poisoning is not dependent on a single predictor as age, lag time, etc.

This incidence of suicidal poisoning is much higher than the recorded range of The fatal issue is often related to a delay in opisoning or an improper management. Patients in the control group received routine emergency treatment, including gastrolavage, catharsis, rehydration, maintenance of water-electrolyte balance, and anti-infection treatment.

OP compounds are used worldwide in agriculture as well as in household gardens. In these cases patients, though on ventilator, keep worsening and die eventually. There was no statistically significant association with death and age, lag time, severity of poisoning and duration of ventilation independently.

Poisoning due to organophosphate insecticides. New Eng J Med. Atropine is highly effective in antagonising the actions of organophosphates at muscarinic receptor sites and is administered to adults in doses of 2 mg every 5 to 10 minutes.